| Field | Specification |
|---|---|
| Alternative names | AZD-6738 formate |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C20H24N6O2S.xCH2O2 |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Ceralasertib formate, also known as AZD-6738 formate, is a potent, selective, and orally active ATR inhibitor with an IC50 of 1 nM. It inhibits cell viability, induces DNA damage and cell senescence, and shows antitumor activity[1][2]. It has the molecular formula C20H24N6O2S.xCH2O2 and a molecular weight of 458.53 g/mol.
Physical & Chemical Properties
| CAS Number | 1352280-98-8 |
|---|---|
| Molecular Formula | C20H24N6O2S.xCH2O2 |
| Molecular Weight | 458.53 g/mol |
| Signaling Pathway | Cell Cycle/DNA Damage; PI3K/Akt/mTOR |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
Ceralasertib formate (0, 0.3, 1 μM; 48 h) causes cell senescence in A549 cells in a dose-dependent manner[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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Different repair pathways support intact or truncated insertions by R2 retrotransposon protein. Science 2026 Feb 26;391(6788):eadz3121. PMID: 41231928
Radiotherapy-resistant prostate cancer cells escape immune checkpoint blockade through the senescence-related ataxia telangiectasia and Rad3-related protein. Cancer Commun (Lond) 2025 Mar;45(3):218-244. PMID: 39698847
Targeting de novo pyrimidine synthesis confers vulnerability to copper-mediated ATR inactivation in PARP inhibitor-resistant ovarian cancer. Nat Commun 2026 Feb 25;17(1):3142. PMID: 41735312
PAF1c links S-phase progression to immune evasion and MYC function in pancreatic carcinoma. Nat Commun 2024 Feb 16;15(1):1446. PMID: 38365788
TP53-dependent toxicity of CRISPR/Cas9 cuts is differential across genomic loci and can confound genetic screening. Nat Commun 2022 Aug 4;13(1):4520. PMID: 35927263
Treacle controls the nucleolar response to rDNA breaks via TOPBP1 recruitment and ATR activation. Nat Commun 2020 Jan 8;11(1):123.
Rapid phosphorylation of glucose-6-phosphate dehydrogenase by casein kinase 2 sustains redox homeostasis under ionizing radiation. Redox Biol 2023 Sep:65:102810. PMID: 37478541
SLFN11-mediated ribosome biogenesis impairment induces TP53-independent apoptosis. Mol Cell 2025 Mar 6;85(5):894-912.e10. PMID: 39909041
The MYCN oncoprotein is an RNA-binding accessory factor of the nuclear exosome targeting complex. Mol Cell 2024 Jun 6;84(11):2070-2086.e20. PMID: 38703770
Human REV1 interacts with DHX36 to promote replication and tolerance of G-quadruplex DNA. Nucleic Acids Res 2026 Jun 8;54(11):gkag562. PMID: 42258547
