| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C14H9F6N5O4 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Cestrin is an inhibitor of plant cellulose synthase complex (CESA) trafficking. It selectively blocks the sustained trafficking of cellulose synthase complexes (CSCs) and the interaction between CSC and POM2, indirectly causing secondary destabilization of cortical microtubules (MTs). It also reduces cellulose content, inhibits anisotropic cell growth, induces cell swelling, and decreases cell elongation, making it applicable to plant cell biology research[1]. It has a molecular formula of C14H9F6N5O4 and a molecular weight of 425.24 g/mol.
Physical & Chemical Properties
| CAS Number | 671181-94-5 |
|---|---|
| Molecular Formula | C14H9F6N5O4 |
| Molecular Weight | 425.24 g/mol |
| SMILES | FC(F)(F)C1=CC(NNC2=C(C=C(C=C2[N+]([O-])=O)C(F)(F)F)[N+]([O-])=O)=NC(C)=C1 |
| Signaling Pathway | Cytoskeleton |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
In hypocotyl cells from 3-day-old etiolated Arabidopsis thaliana, Cestrin (15 μM; 2 h) lowers the average velocity of GFP-CESA3 particles to 127 nm/min, makes GFP-CESA3 vanish from the plasma membrane, and drives it to accumulate in the cortical compartment[1]. Localization and morphology of multiple organelle and trafficking markers are not disrupted by Cestrin (15 μM; 2 h), which indicates a selective action in hypocotyl cells of 3-day-old etiolated Arabidopsis thaliana[1]. Anisotropic growth of hypocotyls in 5-day-old etiolated Arabidopsis thaliana seedlings is inhibited by Cestrin (0-15 μM; 5 d), with an IC50 value of 4.85 μM; cell swelling is induced and elongation is reduced[1]. Cellulose content in 8-day-old etiolated Arabidopsis hypocotyls drops by approximately 30% with Cestrin (9 μM; 8 d)[1]. In 4-day-old etiolated Arabidopsis seedlings, Cestrin (8-15 μM; 2 h) significantly reduces the amount of [13C]glucose incorporated into cellulose and into non-cellulosic cell wall components[1]. In hypocotyl cells of 3-day-old etiolated Arabidopsis thaliana, Cestrin (15 μM; 2 h) cuts the average velocity of GFP-KOR1 particles to 60 nm/min, makes GFP-KOR1 vanish from the plasma membrane, and drives it to accumulate in the cortical compartment[1]. In 3-day-old etiolated Arabidopsis hypocotyl cells, Cestrin (15 μM; 1.5-2 h) applied for 1.5 h lowers the average velocity of POM2/CSI1-3xYpet particles to 164 nm/min, whereas a 2 h treatment induces POM2/CSI1 to dissociate from the cytoplasm[1]. In hypocotyl cells of 3-day-old etiolated Arabidopsis thaliana, Cestrin (15 μM; 2 h) disrupts the structure and stability of cortical microtubules, whereas the dynamics of the actin cytoskeleton remain unaffected[1]. Tubulin polymerization in vitro is not inhibited by Cestrin (15 μM); rather, a slight but significant increase in the polymerization reaction results[1]. Cestrin (15 μM; 2 h) raises the colocalization level of GFP-CESA3 and CFP-SYP61 by approximately 15% in hypocotyl cells of 3-day-old etiolated Arabidopsis thaliana, thereby enriching CSCs in SYP61-associated compartments[1]. In Arabidopsis seedlings of the isoxaflutole-resistant mutant ixr1-1, of wild-type Col-0, and of prc1-1, hypocotyl growth is inhibited by Cestrin (8 μM; 5 d)[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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