| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Concentration | |
| Form | Lyophilized powder. |
| Product Type | |
| Purity | |
| Reconstitution | |
| Shipping | |
| Solubility | Soluble in DMSO and ethanol. Centrifuge before use (10000 x g, 5 min). |
| Source | Synthetic |
| Storage | |
| Target |
Product details
- Chemical name: 5,6,7,8,9,10-Hexahydro-2-(4-methoxyphenyl)cyclohepta[b]pyrazolo[3,4-d]pyridin-3(2H)-one.
- CAS number: 111205-55-1
- Molecular formula: C18H19N3O2.
- Purity: >99%
- Concentration: 1-100 µM.
- Form: Lyophilized powder.
- Solubility: Soluble in DMSO and ethanol. Centrifuge before use (10000 x g, 5 min).
- Reconstitution: Soluble in DMSO and ethanol. Centrifuge before use (10000 x g, 5 min).
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: GABA(A) receptors
- Source: Synthetic
- Activity: CGS 20625 acts as a partial agonist at GABA(A) receptors (EC50 = 11.2-23.7 µM)1. It is a potent and selective non-benzodiazepine ligand at the central benzodiazepine receptor (IC50 = 1.3 nM), with anxiolytic and anticonvulsant effects in vivo2.
Scientific background
CGS 20625 is a synthetic compound that acts as a potent and selective partial agonist of GABA(A) receptors.CGS 20625 is a pyrazolopyridine compound that possesses anxiolytic and anticonvulsant characteristics. It binds to a specific recognition site on GABAA receptors containing α1, α2, α3, and α5 subunits1-3.GABA(A) receptors are members of the Cys-loop superfamily of ligand-gated ion channels. They mediate GABA actions, a major inhibitory neurotransmitter, throughout the central nervous system where it plays an important role in inhibiting cell excitation. GABA(A) receptors are a major target for antiseizure drugs4.
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
Can’t find the compound you’re looking for?
Send the CAS or structure and your specs. We can help source it, suggest close equivalents, or discuss custom synthesis with the right QC documentation (RUO).
