| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | 2,2',3S,3'S,5aR,5'aR,6,6'-octahydro-3,3'-bis(hydroxymethyl)-2,2'-dimethyl-[10bR,10'bR(11aS,11'aS)-bi-3,11a-epidithio-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole]-1,1',4,4'-tetrone |
| Cas No. | |
| Form | Lyophilized Solid |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble in 25 mg/ml DMSO or 25 mg/ml Ethanol |
| Source | Synthetic |
| Storage |
Chaetocin is a fungal-derived inhibitor of the lysine methyltransferase SUV39H1, a key enzyme involved in histone H3 lysine 9 (H3K9) methylation. While primarily studied for its antimyeloma and anticancer properties, Chaetocin has gained attention in neuroscience for its role in epigenetic regulation. By modulating histone methylation, Chaetocin influences gene expression patterns critical to neuronal development, synaptic plasticity, and memory formation. Its ability to alter chromatin structure makes it a valuable tool for investigating the epigenetic mechanisms underlying neurodegenerative diseases such as Alzheimer's and Huntington's. Chaetocin’s cell permeability and specificity for SUV39H1 position it as a promising candidate for exploring therapeutic strategies targeting aberrant histone methylation in the brain.
Classification: Harmful- Harmful by inhalation, in contact with skin, and if swallowed.
Safety Phrases:
- S22 - Do not breathe dust
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
- S24/25- Avoid contact with skin and eyes
Precautionary Statements:
- P280 Wear protective gloves/protective clothing/eye protection/face protection.
- P301+P312- IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
- P304+P340- IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
- P501 Dispose of contents/container in accordance with local/regional/national/international regulations.
Hazard Statements:
- H302- Harmful if swallowed
- H312- Harmful in contact with skin
- H332- Harmful if inhaled
Chaetocin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-351)
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2. Isham, C.R., et al. (2007) Blood. 109: 2579.
