| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Source | Plant — Piperaceae Piper kadsura (Choisy) Ohwi |
| Molecular weight | |
| Molecular formula | C18H23NO3 |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Chingchengenamide A is a naturally occurring alkaloid. The manufacturer sources it from Piper kadsura (Choisy) Ohwi (family Piperaceae) and supplies it as a white to off-white solid (C18H23NO3, MW 301.38) at 96% purity.
Physical & Chemical Properties
| CAS Number | 139906-29-9 |
|---|---|
| Molecular Formula | C18H23NO3 |
| Molecular Weight | 301.38 g/mol |
| Purity | 96% |
| Appearance | Solid |
| Color | White to off-white |
| Structure Classification | Others |
| SMILES | CC(C)CNC(/C=C/C=C/CCC1=CC=C(OCO2)C2=C1)=O |
| Initial Source | Plant — Piperaceae Piper kadsura (Choisy) Ohwi |
| Storage | 4°C, sealed storage, away from moisture and light. In solvent: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
Chingchengenamide A (100 μg; 24 h) shows antimicrobial activity against the gram-positive and gram-negative bacteria tested, with the largest zone of inhibition (21 mm) against Pseudomonas aeruginosa[1]. Favorable ADMET properties are reported for Chingchengenamide A: high human intestinal absorption, good Caco-2 permeability, and non-carcinogenicity[1]. In differentiated Caco-2 cells, Chingchengenamide A (0.1-100 μM; 90 min) increases glucose uptake without affecting fatty acid uptake[2]. Aedes albopictus third instar larvae are potently killed by Chingchengenamide A at 0.00125-0.01 mg/mL over 48 h[3].
In Vivo
In Swiss albino mice, Chingchengenamide A (10-20 mg/kg; p.o.) shows dose-dependent antidiarrheal activity in the Castor oil-induced diarrhea model[1]. In Swiss albino mice, Chingchengenamide A (10-20 mg/kg; p.o.) also shows dose-dependent analgesic activity in the Acetic acid-induced writhing model[1].
| Animal Model | Swiss albino mice induced by Castor oil (4–5 weeks old, both genders)[1] |
|---|---|
| Dosage | 10 mg/kg; 20 mg/kg |
| Administration | p.o. |
| Result | Reduced diarrhea by 33.33% at 10 mg/kg; reduced diarrhea by 40% at 20 mg/kg. |
| Animal Model | Swiss albino mice induced by Acetic acid (4–5 weeks old, both genders)[1] |
|---|---|
| Dosage | 10 mg/kg; 20 mg/kg |
| Administration | p.o. |
| Result | Reduced writhing by 34.69% at 10 mg/kg; reduced writhing by 42.86% at 20 mg/kg. |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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