| Field | Specification |
|---|---|
| Target | |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C20H17Cl2N9O2 |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
CHIR 98024 is an inhibitor of glycogen synthase kinase 3 (GSK3), with an EC50 of 0.2566 μM[1]. It is supplied as a light yellow to yellow solid (C20H17Cl2N9O2, MW 486.31) at 99.20% purity.
Physical & Chemical Properties
| CAS Number | 556813-39-9 |
|---|---|
| Molecular Formula | C20H17Cl2N9O2 |
| Molecular Weight | 486.31 g/mol |
| Purity | 99.20% |
| Appearance | Solid |
| Color | Light yellow to yellow |
| SMILES | NC1=NC(NCCNC2=NC=C(C3=NC=CN3)C(C4=CC=C(Cl)C=C4Cl)=N2)=CC=C1[N+]([O-])=O |
| Target | GSK-3 |
| Signaling Pathway | PI3K/Akt/mTOR; Stem Cell/Wnt |
| Solubility | In Vitro: DMSO: 125 mg/mL (257.04 mM; Requires sonication and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
Activity & Target
|
GSK-3 0.2566 μM (EC50) |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
[1]. Stephen D. Harrison, et al. Methods and compositions for the treatment of ischemia. WO2003074072A1.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 125 mg/mL (257.04 mM) | requires sonication and warming and heat to 60°C; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); avoid repeated freeze-thaw cycles.
Data provided by the manufacturer.
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