Chlormethiazole hydrochloride

Product details

• Chemical name: 5-(2-chloroethyl)-4-methyl-1,3-thiazole;hydrochloride.
• Also known as: Somnevrin hydrochloride
• CAS number: 6001-74-7
• Molecular formula: C6H9Cl2NS.
• Purity: >96%
• Concentration: 0.01-1 mM.
• Form: Lyophilized powder.
• Solubility: Up to 200 mM in H2O. Centrifuge all product preparations before use (10000 x g 5 min).
• Reconstitution: Up to 200 mM in H2O. Centrifuge all product preparations before use (10000 x g 5 min).
• Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
• Target: GABA(A), Glycine receptors
• Source: Synthetic
• Activity: Chlormethiazole both directly activates GABAA receptors (at 0.3 - 1 mM), and potentiates GABA-induced activation at various GABAA receptor subtypes (with EC50 of 20 - 160 µM)1. It was also shown to potentiate glycine-induced currents in both bovine chromaffin cells and murine spinal neurons (at 100 µM)2.
• Alternative names: Somnevrin hydrochloride

Scientific background

Chlormethiazole hydrochloride, a thiazole derivative, is a sedative, hypnotic and anxiolytic compound that has been used for the treatment of alcohol-withdrawal symptoms, status epilepticus and pre-eclampsia.Chlormethiazole acts as a positive modulator of GABA(A) and glycine receptors and holds structural similarity to the β-subunit-selective compound loreclezole. In several studies, the compound was also shown to have neuroprotective properties in models of ischaemia1,2,3.GABA(A) receptors are members of the Cys-loop superfamily of ligand-gated ion channels and mediate GABA action, a major inhibitory neurotransmitter, throughout the central nervous system. GABA(A) receptors are considered to be a major target of antiseizure drugs4.

Lead time: 1-2 Business Days

Country of origin: Israel/IL

Applications key

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Bioassay tested: Yes

• SDS (PDF)

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