| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C27H47N |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Cholesterylamine is a cationic lipid and an analog of cholesterol. It mimics cholesterol's membrane transport behavior, cycling between the plasma membrane and early/recycling endosomes in mammalian cells, and it can serve as a platform for building synthetic cell surface receptors. The compound is also used to prepare PLGA particles bearing surface charges for antigen binding, making it applicable to drug delivery and to research on autoimmune diseases and allergies[1][2]. It is supplied as a white to yellow solid (C27H47N, MW 385.67) at 95.0% purity.
Physical & Chemical Properties
| CAS Number | 2126-93-4 |
|---|---|
| Molecular Formula | C27H47N |
| Molecular Weight | 385.67 g/mol |
| Purity | 95.0% |
| Appearance | Solid |
| Color | White to yellow |
| SMILES | N[C@H]1CC[C@]2(C)[C@@]3([H])CC[C@]4(C)[C@@H]([C@H](C)CCCC(C)C)CC[C@@]4([H])[C@]3([H])CC=C2C1 |
| Signaling Pathway | Metabolic Enzyme/Protease |
| Solubility | In Vitro: Chloroform: ≥ 50 mg/mL (129.64 mM) * "≥" means soluble, but saturation unknown. |
| Storage | -20°C, protect from light, stored under nitrogen. In solvent: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
[1]. Tianxin Wang, et al. Methods, compositions and therapeutical vaccine for autoimmune diseases and allergy treatment. US20220025015A1. 2022-01-27
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| Chloroform | ≥ 50 mg/mL (129.64 mM) | — |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); protect from light, stored under nitrogen; avoid repeated freeze-thaw cycles.
Data provided by the manufacturer.
In Vitro
Cholesterylamine can be used to modify the surface of PLGA nanoparticles, enabling efficient non-covalent adsorption of antigens such as Ovalbumins. This yields antigen-coated nanoparticles for inducing immune tolerance[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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