| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Concentration | |
| Form | Lyophilized powder. |
| Product Type | |
| Purity | |
| Reconstitution | |
| Shipping | |
| Solubility | 10 mM in DMSO. Centrifuge all product preparations before use (10000 x g 1 min). |
| Source | Synthetic |
| Storage | |
| Target |
Product details
- Chemical name: 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl (2E)-3-phenyl-2-propenyl ester.
- CAS number: 132203-70-4
- Molecular formula: C27H28N2O7.
- Purity: >98.5%
- Concentration: 1-100 µM.
- Form: Lyophilized powder.
- Solubility: 10 mM in DMSO. Centrifuge all product preparations before use (10000 x g 1 min).
- Reconstitution: 10 mM in DMSO. Centrifuge all product preparations before use (10000 x g 1 min).
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: L- and N-type Ca2+ channels
- Source: Synthetic
- Activity: Cilnidipine is an L- and N-type Ca2+-channel blocker1.
Peptide confirmation
Confirmed by amino acid analysis and mass spectrometry
Scientific background
Cilnidipine (CIL) is a potent slow-acting, anti-sympathetic drug that inhibits N-type (IC50 = 200 nM) and L-type (IC50 = 100 nM) Ca2+ channels and thus alleviates hypertension occurrences. CIL is essentially a dihydropyridine with slow onset and long-term vasodilation effects. It is considered to be a "fourth generation" anti-hypertension drug, effective both in vivo and in vitro1,2-4.In vivo studies have demonstrated CIL to be helpful in mitigating long QT syndrome in a canine model and to reduce ischemic cardiac norepinephrine levels in rabbit model of cardiac infraction. Clinical trials have shown that CIL is highly effective in cases of severe hypertension, that it improves left ventricular function, and is effective in combating hypertension5-8.
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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