| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Concentration | |
| Form | Lyophilized Powder |
| Product Type | |
| Purity | |
| Shipping | |
| Solubility | Soluble in DMSO up to 100 mM. Centrifuge all products before handling (10000 x g 5 min). |
| Source | Synthetic |
| Storage | |
| Target |
Product details
- CAS number: 486427-17-2
- Also known as: (3-Chlorophenyl)(6,7-dimethoxy-1-((4-methoxyphenoxy)methyl)-3,4-dihydroisoquinolin-2(1 H)-yl)methanone
- Molecular formula: C26H26ClNO5.
- Purity: >99% (HPLC)
- Concentration: 1-20 µM.
- Form: Lyophilized Powder
- Solubility: Soluble in DMSO up to 100 mM. Centrifuge all products before handling (10000 x g 5 min).
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: NMDA receptors
- Source: Synthetic
- Activity: CIQ is an NR2C and NR2D selective potentiator of NMDA receptors. It enhances receptor responses two-fold with EC50 of 3 µM by increasing channel opening frequency1.
- Alternative names: (3-Chlorophenyl)(6,7-dimethoxy-1-((4-methoxyphenoxy)methyl)-3,4-dihydroisoquinolin-2(1 H)-yl)methanone
Scientific background
CIQ is a positive allosteric potentiator selective for NR2C- and NR2D-containing N-methyl-d-aspartate (NMDA) receptors. The compound does not potentiate other NMDA receptor subtypes or AMPA and kainate receptors. The activity of CIQ depends on a single residue in the M1 region of the receptor1,2. CIQ demonstrates potentiating EC50 values of 2.7 and 2.8 μM for NR2C- and NR2D-containing receptors, respectively1.NMDA receptors are tetrameric entities composed of two obligatory GluN1 and two GluN2 subunits. They play important roles in numerous cellular processes and brain functions such as synaptic plasticity, addiction, and stroke. NMDA receptors also mediate physiological functions such as learning and memory formation. They are also involved in many neurodegenerative conditions including Alzheimer's disease2,3.
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
Can’t find the compound you’re looking for?
Send the CAS or structure and your specs. We can help source it, suggest close equivalents, or discuss custom synthesis with the right QC documentation (RUO).
