| Field | Specification |
|---|---|
| Alternative names | PER977 TFA |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C26H50F6N12O6 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Ciraparantag TFA, also known as PER977 TFA, is an inhibitor of thrombin and factor Xa. It is a broad-spectrum reversal agent for anticoagulants, including low-molecular-weight heparin, unfractionated heparin, and certain direct oral anticoagulants, and it is reported to antagonize the effects of all coagulants except VKAs and agratroban[1][2][3][4]. It has a molecular formula of C26H50F6N12O6 and a molecular weight of 740.74 g/mol.
Physical & Chemical Properties
| CAS Number | 1438492-27-3 |
|---|---|
| Molecular Formula | C26H50F6N12O6 |
| Molecular Weight | 740.74 g/mol |
| SMILES | O=C(NCCCN1CCN(CCCNC([C@@H](N)CCCNC(N)=N)=O)CC1)[C@@H](N)CCCNC(N)=N.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F |
| Signaling Pathway | Metabolic Enzyme/Protease |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
Ciraparantag TFA is a small, synthetic, cationic molecule. Via non-covalent hydrogen bonds and charge–charge interactions, it binds direct Xa inhibitors and direct thrombin inhibitors, as well as unfractionated heparin and low molecular weight heparin (LMWH)[3].
In Vivo
Ciraparantag (PER977) TFA reverses anticoagulants and reduces bleeding in rat-tail transection bleeding assays, as shown by thromboelastography studies[3].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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