| Field | Specification |
|---|---|
| Target | |
| Alternative names | TMCB |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C11H9Br4N3O2 |
| Activity | |
| Signaling pathway | |
| SMILES | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
CK2/ERK8-IN-1 (CAS 1085822-09-8) is a research-grade small molecule supplied by TargetMol.
Alternative names: TMCB
Physical Properties
| CAS Number | 1085822-09-8 |
|---|---|
| Molecular Formula | C11H9Br4N3O2 |
| Molecular Weight | 534.82 g/mol |
| SMILES | C(C(O)=O)N1C=2C(N=C1N(C)C)=C(Br)C(Br)=C(Br)C2Br |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
CK2/ERK8-IN-1 (TMCB) is a dual inhibitor of casein kinase 2 (CK2) (Ki: 0.25 uM) and ERK8 (IC50s: 0.50 uM) with pro-apoptotic efficacy. CK2/ERK8-IN-1 also binds to PIM1, DYRK1A, and HIPK2 (Kis: 8.65 uM, 11.9 uM, and 15.25 uM).
Target(s): DYRK, Casein Kinase, Pim, Apoptosis, ERK
Signaling pathway(s): MAPK, Apoptosis, Chromatin/Epigenetic, JAK/STAT signaling, Metabolism, Stem Cells, Tyrosine Kinase/Adaptors, Cell Cycle/Checkpoint
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
Use a bath-type ultrasonic cleaner at standard cleaning frequency (37–40 kHz). Bath sonication is gentler than a probe sonicator and avoids sample overheating. Sonicate in 5–10 second intervals, checking solubility between pulses, for no more than 2–3 minutes total. Warm the bath to 37 °C if solubility remains poor.
Use a bath-type ultrasonic cleaner rather than a high-intensity ultrasonic disruptor. Bath sonicators provide gentle, uniform agitation appropriate for dissolving solid compounds without generating cavitation damage or excessive heat. Ensure the solvent tube is fully submerged and use short sonication pulses of 5–10 seconds.
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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