Clozapine

Clozapine is an atypical antipsychotic widely recognized for its efficacy in treatment-resistant schizophrenia. It acts as a multi-receptor antagonist, particularly targeting serotonin (5-HT2A/2C) and dopamine receptors, which are critical in modulating mood, cognition, and perception. In neuroscience, Clozapine is frequently cited for its unique pharmacological profile that contributes to reduced extrapyramidal side effects and improved cognitive outcomes. Its influence on glutamatergic and cholinergic systems has also made it a subject of interest in neurodegenerative disease research, including Parkinson’s and Alzheimer’s disease. Clozapine’s neuroprotective and anti-inflammatory properties further enhance its relevance in studying the pathophysiology of neuropsychiatric and neurodegenerative disorders.

Classification: D1B Toxic Material Causing Immediate and Serious Toxic Effects - Toxic by ingestion

D2A Very Toxic Material Causing Other Toxic Effects - Teratogen

D2B Toxic Material Causing Other Toxic Effects - Carcinogen, Moderate eye irritant, Mutagen

Hazard statement(s):

• H301 Toxic if swallowed.
• H341 Suspected of causing genetic defects.
• H351 Suspected of causing cancer.
• H361 Suspected of damaging fertility or the unborn child.

Precautionary statement(s):

• P281 Use personal protective equipment as required.
• P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician.

Clozapine (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-541)

Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.

• Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
• Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
• Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
• QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
• Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity

To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).

Can’t find the compound you’re looking for?
Send the CAS or structure and your specs. We can help source it, suggest close equivalents, or discuss custom synthesis with the right QC documentation (RUO).