| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C42H30Na2O8P2 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
CLR01 sodium is an anti-aggregation agent that crosses the blood-brain barrier. It blocks the de novo aggregation of Amyloid-β 40/42, α-synuclein, IAPP, tau protein, and SOD1, and in triple-transgenic mice it lowers cortical amyloid plaque burden while improving memory and motor abilities. It can be used in research on Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS)[1]. It has a molecular formula of C42H30Na2O8P2 and a molecular weight of 770.61 g/mol.
Physical & Chemical Properties
| CAS Number | 1338489-62-5 |
|---|---|
| Molecular Formula | C42H30Na2O8P2 |
| Molecular Weight | 770.61 g/mol |
| SMILES | O=P(O)(O[Na])OC1=C2C([C@]3([H])C[C@@]2([H])C4=CC([C@]5([H])C6=CC=CC=C6[C@@]7([H])C5)=C7C=C43)=C(C8=C1[C@@]9([H])C%10=CC([C@@]%11([H])C%12=CC=CC=C%12[C@]%13([H])C%11)=C%13C=C%10[C@]8([H])C9)OP(O)(O[Na])=O |
| Signaling Pathway | Neuronal Signaling; GPCR/G Protein; Immunology/Inflammation |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
CLR01 binds the N-terminal lysine of the KLVFF peptide in PBS buffer, with a Kd of 10 μM[1].
In Vivo
In triply transgenic Alzheimer's disease mice, CLR01 (40 μg/kg; daily) lowers cortical plaque load and improves memory and mobility at this daily dose of 40 μg/kg[1]. In G93A-SOD1 ALS mice, CLR01 significantly reduces misfolded SOD1 in the spinal cord but does not improve motor function in this fast-progressing model[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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