CMPDA

Product details

• Chemical name: N,N'-(1,4-phenylenedi-2,1-ethanediyl­)bis-2-propanesulfonamide.
• CAS number: 380607-77-2
• Molecular formula: C16H28N2O4S2.
• Purity: >99.9%
• Concentration: 40 nM - 10 µM.
• Form: Lyophilized powder.
• Solubility: 100 mM in DMSO. Centrifuge all product preparations before use (10000 x g for 1 min).
• Reconstitution: Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in sterile water at a concentration of at least 0.1 mg/mL. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. It is recommended to prepare fresh solutions in working buffers just before use. For long-term storage of diluted solutions, we recommend adding 0.1% BSA. Repeat freeze-thawing may result in loss of activity.
• Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
• Target: AMPA receptors
• Source: Synthetic
• Activity: CMPDA is a selective AMPA receptor agonist (allosteric potentiator). EC50 = 45.4 and 63.4 nM at GluR2i and GluR2o respectively, in a calcium influx screening assay1.

Peptide confirmation

Confirmed by amino acid analysis and mass spectrometry

Scientific background

CMPDA is a novel positive allosteric modulator of AMPA receptors. Such allosteric modulators act by enhancing normal AMPA receptor activity to mimic long-term potentiation and prolong open-channel time by slowing or preventing channel closure. Slowing the termination of a glutamate-evoked response enhances excitatory postsynaptic potentials by increasing ion flux through AMPA receptor channels1. CMPDA modulates AMPA subunit GluA2 receptor (GluR2) and its desensitization and deactivation (EC50 = 45.4 and 63.4 nM at GluR2i and GluR2o respectively, in a calcium influx screening assay of GluA2i and GluA2o receptors expressed in HEK293 cells). This compound binds at the modulator binding pocket located at the interdimer interface and the clamshell hinges2. This pocket is a powerful target for drug discovery of compounds that modulate AMPA receptors and is a possible site of action for endogenous metabolites.

Lead time: 1-2 Business Days

Country of origin: Israel/IL

Applications key

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Bioassay tested: Yes

• SDS (PDF)

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• Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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