| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Source | Microbial — Streptomyces rishiriensis. |
| Molecular weight | |
| Molecular formula | C55H59N5O20 |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Coumermycin A1 activates JAK2 signaling. It inhibits DNA gyrase, thereby blocking cell division in bacteria, and shows anti-orthopoxvirus activity. It is supplied as a white to off-white solid (C55H59N5O20, MW 1110.08) at 99.86% purity.
Physical & Chemical Properties
| CAS Number | 4434-05-3 |
|---|---|
| Molecular Formula | C55H59N5O20 |
| Molecular Weight | 1110.08 g/mol |
| Purity | 99.86% |
| Appearance | Solid |
| Color | White to off-white |
| Structure Classification | Antibiotics |
| SMILES | OC(C1=CC=C(O[C@@H]([C@H](O)[C@H](OC(C2=CC=C(C)N2)=O)[C@H]3OC)OC3(C)C)C(C)=C1O4)=C(NC(C5=CNC(C(NC6=C(O)C7=CC=C(O[C@@H]([C@H](O)[C@H](OC(C8=CC=C(C)N8)=O)[C@H]9OC)OC9(C)C)C(C)=C7OC6=O)=O)=C5C)=O)C4=O |
| Signaling Pathway | Protein Tyrosine Kinase/RTK; JAK/STAT Signaling; Epigenetics; Stem Cell/Wnt; Anti-infection |
| Initial Source | Microbial — Streptomyces rishiriensis. |
| Solubility | In Vitro: DMSO: 10 mg/mL (9.01 mM; Requires sonication and warming and adjust pH to 2 with 1 M HCl and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 10 mg/mL (9.01 mM) | requires sonication and warming and adjust pH to 2 with 1 M HCl and heat to 60°C; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); avoid repeated freeze-thaw cycles.
Data provided by the manufacturer.
In Vitro
JAK2 signal activation induced by Coumermycin A1 raises the mRNA level of SCOS2 and lowers the leptin receptor mRNA level[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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Targeting JAK2 with a multifunctional nanoinhibitor for long-lasting anti-inflammatory effects and bone repair. J Nanobiotechnology 2025 Oct 10;23(1):649. PMID: 41074120
A CD36-dependent non-canonical lipid metabolism program promotes immune escape and resistance to hypomethylating agent therapy in AML. Cell Rep Med 2024 Jun 18;5(6):101592. PMID: 38843841
Baicalin ameliorates dextran sulfate solidum-induced colitis by modulating Th17-macrophage immune network via JAK2/STAT3/IL-17/NF-κB pathway. Phytomedicine 2025 Nov 25:148:157414. PMID: 41124707
Karanjin counteracts OVX-induced bone loss by dual regulating bone remodeling. Phytomedicine 2025 Oct:146:157099. PMID: 40774011
Hesperidin Inhibits Oxidative Stress and Apoptosis of Granulosa Cells in Polycystic Ovarian Syndrome Through the JAK2/STAT3 and PI3K/AKT Pathways. Phytother Res 2025 Sep 27. PMID: 41014201
Adipocyte fatty acid-binding protein as a cerebrospinal fluid-accessible biomarker and druggable target in subarachnoid haemorrhage: Linking fatty acid dysregulation to microglial neuroinflammation. Clin Transl Med 2026 Feb;16(2):e70607. PMID: 41612866
Eriocalyxin B ameliorated Crohn's disease-like colitis by restricting M1 macrophage polarization through JAK2/STAT1 signalling. Eur J Pharmacol 2023 Sep 5:954:175876. PMID: 37391008
NLRP3 regulates ferroptosis via the JAK2/STAT3 pathway in asthma inflammation: Insights from in vivo and in vitro studies. Int Immunopharmacol 2024 Oct 18;143(Pt 2):113416. PMID: 39426227
Piceatannol-mediated JAK2/STAT3 signaling pathway inhibition contributes to the alleviation of oxidative injury and collagen synthesis during pulmonary fibrosis. Int Immunopharmacol 2022 Oct:111:109107. PMID: 35932616
Fibroblast Growth Factor 21 Relieves Lipopolysaccharide-Induced Acute Lung Injury by Suppressing JAK2/STAT3 Signaling Pathway. Inflammation 2024 Feb;47(1):209-226. PMID: 37864659
