| Field | Specification |
|---|---|
| Target | |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C20H25Cl2F3N2O2 |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
CP 122721 hydrochloride is a potent, selective, non-peptide neurokinin NK1 antagonist, with a pIC50 of 9.8 for the human NK1 receptor expressed in IM-9 cells. It exhibits anxiolytic and antidepressant-like effects[1][2]. It is supplied as a white to off-white solid (C20H25Cl2F3N2O2, MW 453.33) at 99.63% purity.
Physical & Chemical Properties
| CAS Number | 145877-52-7 |
|---|---|
| Molecular Formula | C20H25Cl2F3N2O2 |
| Molecular Weight | 453.33 g/mol |
| Purity | 99.63% |
| Appearance | Solid |
| Color | White to off-white |
| SMILES | COC1=C(C=C(C=C1)OC(F)(F)F)CN[C@H]2CCCN[C@H]2C3=CC=CC=C3.Cl.Cl |
| Target | human NK1 |
| Signaling Pathway | GPCR/G Protein; Neuronal Signaling |
| Storage | -20°C, sealed storage, away from moisture. In solvent: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
IC50 & Target[1]
|
human NK1 9.8 (pIC50) |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
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