| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Concentration | |
| Form | Lyophilized Powder |
| Product Type | |
| Purity | |
| Reconstitution | |
| Shipping | |
| Solubility | 20 mM in DMSO. Centrifuge all product preparations before use (10000 x g for 1 min). |
| Source | Synthetic |
| Storage | |
| Target |
Product details
- Chemical name: N-[1-(Phenylmethyl)-4(1H)-quinolinylidene]-1 pentanamine hydrochloride.
- CAS number: 185855-91-8
- Molecular formula: C21H25ClN2.
- Purity: >98%
- Concentration: 1-200 µM.
- Form: Lyophilized Powder
- Solubility: 20 mM in DMSO. Centrifuge all product preparations before use (10000 x g for 1 min).
- Reconstitution: 20 mM in DMSO. Centrifuge all product preparations before use (10000 x g for 1 min).
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: KV1.3, KV1.4 K+ channels
- Source: Synthetic
- Activity: CP 339818 hydrochloride is a KV1.3 and KV1.4 channel blocker1.
Peptide confirmation
Confirmed by amino acid analysis and mass spectrometry
Scientific background
CP 339818 hydrochloride is a potent KV1.3 channel antagonist that preferentially binds to the C-type inactivated state of the channel. It appears to recognize only the inactivated conformation of KV1.3. CP 339818 hydrochloride inhibits KV1.3 expressed in the brain and in T lymphocyte cells with an IC50 value of ~200 nM. In addition to its effect on KV1.3, CP 339818 inhibits the Shaker-related A-type K+ channel, KV1.4, expressed in brain cells with an IC50 of ~300 nM. CP 339818 is a significantly less potent blocker at KV1.1, KV1.2, KV1.5, KV1.6, KV3.1-4, and KV4.2. CP 339818 is valuable for immune system studies, where the absence of KV1.4 makes it functionally selective for KV1.3, and it has shown suppression of T cell activation. CP 339818 hydrochloride is also valuable for the study of KV1.4 function1.
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
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