| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Concentration | |
| Form | Lyophilized powder. |
| Product Type | |
| Purity | |
| Reconstitution | |
| Shipping | |
| Solubility | Soluble in DMSO. Centrifuge all product preparations before use (10000 x g 5 min). |
| Source | Synthetic |
| Storage | |
| Target |
Product details
- Chemical name: Ethyl (7Z)-7-hydroxyimino-1,7a-dihydrocyclopropa[b]chromene-1a-carboxylate.
- CAS number: 179067-99-3
- Molecular formula: C13H13NO4.
- Purity: >98%
- Concentration: 10-200 µM.
- Form: Lyophilized powder.
- Solubility: Soluble in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
- Reconstitution: Soluble in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: mGluR1
- Source: Synthetic
- Activity: CPCCOEt is a selective, non-competitive antagonist of mGluR1 receptors, inhibiting hmGluR1b with IC50 of 6.5 µM, whilst having no effect at 100 µM on a range of other receptor subtypes1. It was shown to inhibit synaptic activation of mGluR1 in Purkinje cell cerebellar slices with IC50 of 37µM2.
Scientific background
CPCCOEt is a compound that acts as a selective, non-competitive antagonist of mGluR1. It can inhibit mGluR1 signaling without affecting glutamate binding1. CPCCOEt selectively inhibits mGluR1b-induced increases in intracellular calcium and demonstrates IC50 of 6.5 µM1.Glutamate is the most abundant excitatory neurotransmitter in the central nervous system. It modulates the activity of many types of synapses by activating metabotropic glutamate receptors (mGluRs), members of the G-protein coupled receptor (GPCR) superfamily. These receptors are divided into three groups based on sequence homology with a total of eight subtypes, mGluR1 to mGluR8.mGluR1 from group I, plays an important role in the central sensitization of pain and in a variety of physiological functions including regulation of ion channels, synaptic transmission, and plasticity1,2.
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
Can’t find the compound you’re looking for?
Send the CAS or structure and your specs. We can help source it, suggest close equivalents, or discuss custom synthesis with the right QC documentation (RUO).
