| Field | Specification |
|---|---|
| Mfr No | |
| Accession Number | |
| Alternative Names | 10kDa Chaperonin, Chaperonin 10, Cpn 10, EPF, GROES, Heat Shock 10kD protein1, HSP10, HSPE1 |
| Cellular Localization | |
| Clonality | |
| Concentration | |
| Host | |
| Immunogen | Human Cpn10 peptide AA 91-101 |
| Product Type | |
| Reactivity | |
| Shipping | |
| Storage | |
| Target |
Cpn10 (Chaperonin 10), a member of the HSP10 family, functions as a co-chaperone with HSP60 to facilitate proper protein folding and assembly. It is essential for maintaining proteostasis, particularly under stress conditions such as oxidative damage and inflammation.
In the nervous system, Cpn10 supports mitochondrial protein folding and cellular resilience. Its identification as early pregnancy factor and presence in serum suggest systemic regulatory roles, potentially acting as a stress-responsive signaling molecule.
Given the central role of protein misfolding in neurodegenerative diseases like Alzheimer’s and Parkinson’s, Cpn10 is a candidate for therapeutic exploration in modulating chaperone networks and preventing proteotoxicity.
1 µg/ml of SPC-193 was sufficient for detection of Cpn10 in 10 µg of Hela lysates by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.
Cite this product varies by variant:
- SPC-193D — Size: 100 ug: Cpn10 Antibody (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-193D, RRID: AB_2119080)
- SPC-193D-A390 — Size: 100 ug: Cpn10 Antibody: ATTO 390 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-193D-A390, RRID: AB_2704044)
- SPC-193D-A488 — Size: 100 ug: Cpn10 Antibody: ATTO 488 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-193D-A488, RRID: AB_2704045)
- SPC-193D-A594 — Size: 100 ug: Cpn10 Antibody: ATTO 594 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-193D-A594, RRID: AB_2704047)
- SPC-193D-APC — Size: 100 ug: Cpn10 Antibody: APC (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-193D-APC, RRID: AB_2704053)
- SPC-193D-BI — Size: 100 ug: Cpn10 Antibody: Biotin (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-193D-BI, RRID: AB_2704054)
- SPC-193D-FITC — Size: 100 ug: Cpn10 Antibody: FITC (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-193D-FITC, RRID: AB_2704055)
- SPC-193D-HRP — Size: 100 ug: Cpn10 Antibody: HRP (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-193D-HRP, RRID: AB_2704056)
- SPC-193D-PCP — Size: 100 ug: Cpn10 Antibody: PerCP (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-193D-PCP, RRID: AB_2704058)
- SPC-193D-RPE — Size: 100 ug: Cpn10 Antibody: RPE (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-193D-RPE, RRID: AB_2704059)
- SPC-193S — Size: 12 ug: Cpn10 Antibody (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-193S, RRID: AB_2119080)
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
2. Morton H., Hegh V., and Clunie G.J.A. (1974) Nature (London) 249: 459-460.
3. Cavanagh A.C., and Morton H. (1994) Eur. J. Biochem. 222: 551-560.
4. Minto M., et al. (1998) Molecular Cell Research. 1403 (2): 151-157.
