| Field | Specification |
|---|---|
| Alternative names | CRT0066051 |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C28H30N4O2 |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
CRT5, also known as CRT0066051, is a pyrazine benzamide that potently and selectively inhibits all three isoforms of PKD in VEGF-treated endothelial cells, with IC50 values of 1 nM, 2 nM and 1.5 nM for PKD1, PKD2 and PKD3, respectively. It decreases VEGF-induced endothelial migration, proliferation and tubulogenesis[1]. It is supplied as a white to off-white solid (C28H30N4O2, MW 454.56) at 98.70% purity.
Physical & Chemical Properties
| CAS Number | 1034297-58-9 |
|---|---|
| Molecular Formula | C28H30N4O2 |
| Molecular Weight | 454.56 g/mol |
| Purity | 98.70% |
| Appearance | Solid |
| Color | White to off-white |
| SMILES | O=C(NCCN(C)C)C1=CC=CC(C2=CC(C3=CC=C4C=C(OCC)C=CC4=C3)=C(N)N=C2)=C1 |
| Signaling Pathway | Apoptosis |
| Storage | -20°C, sealed storage, away from moisture. In solvent: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
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