| Field | Specification |
|---|---|
| Applications | |
| Molecular weight | |
| Molecular formula | C22H21ClN4O4 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
CTL-12 is an inhibitor of fatty acid synthase (FASN), with an IC50 of 2.5 μM, and it can induce apoptosis. It arrests the cell cycle at the Sub-G1/S phase, increases expression of caspase-9 and the apoptosis marker Bax, and decreases the anti-apoptotic marker Bcl-xL. CTL-12 also inhibits de novo lipogenesis and limits the metabolic demands of tumor cells, and it has been used in breast and colorectal cancer research[1]. It has the molecular formula C22H21ClN4O4 and a molecular weight of 440.88 g/mol.
Physical & Chemical Properties
| Molecular Formula | C22H21ClN4O4 |
|---|---|
| Molecular Weight | 440.88 g/mol |
| SMILES | O=C(C1=CC=C2C(N=C(C3=C(O)C=CC(Cl)=C3)N2)=C1)N4CCN(C(C5(O)CC5)=O)CC4 |
| Signaling Pathway | Metabolic Enzyme/Protease |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
IC50 & Target
IC50: 2.5 μM (FASN)[1]
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
[1]. Singh S, et al. Design, synthesis, and anticancer activity of some novel 1H-benzo [d] imidazole-5-carboxamide derivatives as fatty acid synthase inhibitors[J]. Bioorganic Chemistry, 2023: 106658....
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
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