| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Source | Plant — Cucurbitaceae Hemsleya gigantha W. J. Chang |
| Molecular weight | |
| Molecular formula | C30H46O7 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Cucurbitacin F is a tetracyclic protostane-type triterpenoid related to Cucurbitacin B that shows low toxicity along with antibacterial and anti-inflammatory activity, and occurs widely in plants such as those of the Cucurbitaceae family, Quisqualis indica and Sorbaria sorbifolia. It functions as an actin aggregator, reducing cell viability in a dose-dependent manner, and induces apoptosis by triggering G2/M phase cell cycle arrest together with caspase-3-dependent apoptotic activation[1][2][3][4][5]. It has the molecular formula C30H46O7 and a molecular weight of 518.68 g/mol.
Physical & Chemical Properties
| CAS Number | 5939-57-1 |
|---|---|
| Molecular Formula | C30H46O7 |
| Molecular Weight | 518.68 g/mol |
| Structure Classification | Terpenoids Triterpenes |
| SMILES | C[C@]12[C@@]([C@@]([C@@H](C1)O)([H])[C@@](C)(O)C(/C=C/C(C)(O)C)=O)(CC([C@@]3([C@@]2([H])CC=C4[C@@]3([H])C[C@@H]([C@H](C4(C)C)O)O)C)=O)C |
| Signaling Pathway | Anti-infection; Apoptosis |
| Initial Source | Plant — Cucurbitaceae Hemsleya gigantha W. J. Chang |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
[4]. Lee S M, et al. Toxic evaluation and chromatographic analysis of cucurbitacin D and F from Sorbaria sorbifolia[J]. Analytical Science and Technology, 2001, 14(2): 191-195.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
Cucurbitacin F is significantly cytotoxic to several unspecified tumor cell lines, with an ED50 of <0.1 μg/mL[4].
In Vivo
Cucurbitacin F (2.5 mg/kg/day; daily) causes acute toxicity in BDF-1 mice[4].
| Animal Model | BDF-1 Mice[4] |
|---|---|
| Dosage | 2.5 mg/kg/day |
| Administration | daily |
| Result | Observed acute toxicity in BDF-1 mice. |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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