| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Concentration | |
| Form | Lyophilized powder. |
| Product Type | |
| Purity | |
| Reconstitution | |
| Shipping | |
| Solubility | Up 100 mM in DMSO. Centrifuge all product preparations before use (5,000 x g for 1 min). |
| Source | Natural |
| Storage | |
| Target |
Product details
- Chemical name: (1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione.
- Also known as: Diferuloylmethane, Natural yellow 3, Turmeric yellow, Turmeric
- CAS number: 458-37-7
- Molecular formula: C21H20O6.
- Purity: >96%
- Concentration: 10-200 µM.
- Form: Lyophilized powder.
- Solubility: Up 100 mM in DMSO. Centrifuge all product preparations before use (5,000 x g for 1 min).
- Reconstitution: Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in sterile water at a concentration of at least 0.1 mg/mL. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. It is recommended to prepare fresh solutions in working buffers just before use. For long-term storage of diluted solutions, we recommend adding 0.1% BSA. Repeat freeze-thawing may result in loss of activity.
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: TRPA1 channels
- Source: Natural
- Activity: Curcumin activates TRPA1 channels with an EC50 of 10 µM1.
- Alternative names: Diferuloylmethane, Natural yellow 3, Turmeric yellow, Turmeric
Peptide confirmation
Confirmed by amino acid analysis and mass spectrometry
Scientific background
Transient receptor potential ankyrin 1 (TRPA1) is a non-selective ion channel expressed in nociceptor sensory neurons and transduces chemical, inflammatory, and neuropathic pain signals. Numerous non-reactive compounds and electrophilic compounds, such as endogenous inflammatory mediators and exogenous pungent chemicals, can activate TRPA11.Curcumin is a natural agonist of TRPA1 channels produced from the root Curcuma longa L. with an effective concentration of 10-200 μM and an EC50 of 10 μM. Curcumin is hypothesized to be effective in the prevention and alleviation of various pathologies. Curcumin significantly lowers oxidized proteins, GFAP marker levels and β-amyloid plaques in a mouse model of Alzheimer's disease2. In rats, curcumin reduces liver damage caused by gastric ethanol infusion. This is mainly done by decreasing hepatic MDA, inhibiting NF-κB activation and reducing apoptosis of hepatic cells thus improving hepatic histopathology and reducing the morbidity associated with alcoholic liver disease3. Also, MDX mice treated with curcumin show improvement of grip strength in a dose-dependent manner and a reduction of the CK marker which indicates skeletal muscle injury4.
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
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