| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | (3β,22S,23R)-17,23-Epoxyveratraman-3-ol |
| Cas No. | |
| Form | White Solid |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble to 5 mM in ethanol |
| Source | Synthetic |
| Storage |
Cyclopamine is a steroidal alkaloid that inhibits the Hedgehog signaling pathway by antagonizing the Smoothened receptor. In neuroscience, it is being explored for its role in modulating γ-secretase-mediated cleavage of amyloid precursor protein, a key process in Alzheimer's disease pathology. Cyclopamine’s ability to influence developmental signaling pathways also makes it a valuable tool in neurodevelopmental research.
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin.
Safety Phrases:
- S22 - Do not breathe dust
- S24/25 - Avoid contact with skin and eyes
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Risk Phrases:
R62- Possible risk of impaired fertility
Cyclopamine (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-226)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
Can’t find the compound you’re looking for?
Send the CAS or structure and your specs. We can help source it, suggest close
equivalents, or discuss custom synthesis with the right QC documentation (RUO).
2. Yauch R.L., et al. (2009) Science. 326(5952): 572-574. 3. Vorobyeva A.G., et al. (2014) J Biol Chem. 289(48): 33258-33274.
