| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | 6-Chloro-3,4-dihydro-3-(5-norbornen-2-yl)-2H-1,2,4-benzothiadiazine-7-sulfonamide-1,1-dioxide; LY-35483 |
| Cas No. | |
| Form | Off-white powder |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | May be dissolved in DMSO (35 mg/ml); or ethanol (9 mg/ml) |
| Source | Synthetic |
| Storage |
Cyclothiazide is a positive allosteric modulator of AMPA receptors that enhances excitatory synaptic transmission by inhibiting receptor desensitization. In neuroscience, it is used to study synaptic plasticity, learning, and memory. Cyclothiazide is also employed in models of epilepsy and excitotoxicity to investigate the role of glutamatergic signaling in neuronal survival and death. Its ability to potentiate AMPA receptor activity makes it a valuable compound for exploring excitatory neurotransmission and its dysregulation in neurodegenerative diseases.
Hazard statement(s):
- H315 Causes skin irritation
- H319 Causes serious eye irritation
- H335 May cause respiratory irritation
Precautionary statement(s):
- P260 Do not breathe dust/fume/gas/mist/vapours/spray
- P264 Wash hands thoroughly after handling
- P280 Wear protective gloves/protective clothing/eye protection/face protection
- P302+352 IF ON SKIN: Wash with soap and water
- P304+340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing
- P305+351+338 IF IN EYES: Rinse continuously with water for several minutes. Remove contact lenses if present and
- easy to do so - continue rinsing
- P333+313 If skin irritation or a rash occurs: Get medical advice/attention
Cyclothiazide (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-574)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
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Send the CAS or structure and your specs. We can help source it, suggest close
equivalents, or discuss custom synthesis with the right QC documentation (RUO).
