| Field | Specification |
|---|---|
| Target | |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C54H63N7O11 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
CypD-IN-4 is a potent, subtype-selective inhibitor of cyclophilin D (CypD), with a CypD binding affinity of IC50 0.057 μM. It can be used in the research of several conditions, including oxidative stress, neurodegenerative disorders, liver diseases, aging, autophagy, and diabetes[1]. Its molecular formula is C54H63N7O11, with a molecular weight of 986.12 g/mol.
Physical & Chemical Properties
| CAS Number | 3023438-19-6 |
|---|---|
| Molecular Formula | C54H63N7O11 |
| Molecular Weight | 986.12 g/mol |
| SMILES | NCCOCCNC([C@@H]1CCNC(/C=C/C(N2CCC[C@](C2)(C(N[C@H](C(NCC3=C(CC(N1)=O)C=CC=C3)=O)CC4=CC=C(C=C4)C5=CC=C(C=C5)C(CC(O)=O)CC(O)=O)=O)CC6=CC=CC=C6)=O)=O)=O |
| Target | Cyclophilin D, Cyclophilin A, Cyclophilin B, Cyclophilin E |
| Signaling Pathway | Immunology/Inflammation |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
IC50 & Target
|
Cyclophilin D 0.057 μM (IC50) |
Cyclophilin A 3.4 μM (IC50) |
Cyclophilin B 1.1 μM (IC50) |
Cyclophilin E 0.8 μM (IC50) |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
CypD-IN-4 (B53) selectively inhibits CypD, CypA, CypB and CypE, with IC50 values of 0.057 μM for CypD, 3.4 μM for CypA, 1.1 μM for CypB and 0.8 μM for CypE[1]. In isolated mitochondria, CypD-IN-4 (20 μM) inhibits opening of the mitochondrial permeability transition pore[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
Can’t find the compound you’re looking for?
Send the CAS or structure and your specs. We can help source it, suggest close equivalents, or discuss custom synthesis with the right QC documentation (RUO).
