| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | N-{2-[(5-Chloro-2-{[2-methoxy-4-(4-morpholinyl)phenyl]amino}-4-pyrimidinyl)amino]phenyl}methanesulfonamide hydrochloride |
| Cas No. | |
| Form | Yellow solid |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble to 100 mM in DMSO |
| Source | Synthetic |
| Storage |
CZC 54252 Hydrochloride is a potent and selective inhibitor of leucine-rich repeat kinase 2 (LRRK2), a kinase genetically linked to familial and sporadic Parkinson’s disease. LRRK2 mutations are associated with altered kinase activity, leading to impaired autophagy, mitochondrial dysfunction, and neuroinflammation. CZC 54252 is widely used in Parkinson’s disease research to study the effects of LRRK2 inhibition on neuronal survival, protein clearance, and inflammatory responses. Its selectivity and potency make it a valuable tool for validating LRRK2 as a therapeutic target in neurodegeneration.
Classification: Not a hazardous substance or mixture.
Safety Phrases:
- S22 - Do not breathe dust.
- S24/25 - Avoid contact with skin and eyes.
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
CZC 54252 Hydrochloride (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-439)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
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