D-AP5

D-AP5 (D-(-)-2-Amino-5-phosphonopentanoic acid) is a selective, competitive antagonist of the NMDA receptor, specifically targeting the glutamate binding site. NMDA receptors are critical for synaptic plasticity, learning, and memory, but their overactivation leads to excitotoxicity—a key contributor to neuronal death in neurodegenerative diseases such as Alzheimer’s, Huntington’s, and ALS. D-AP5 is widely used in neuroscience to investigate NMDA receptor-mediated signaling, synaptic transmission, and neuroprotection. By blocking excitotoxic calcium influx, D-AP5 serves as a valuable tool for studying mechanisms of neuronal injury and for developing therapeutic strategies aimed at modulating glutamatergic dysfunction in the CNS.

Classification: D2B Toxic Material Causing Other Toxic Effects, Moderate skin irritant, Moderate respiratory irritant, Moderate eye irritant

Safety Phrases:

• S22 - Do not breathe dust.
• S24/25 - Avoid contact with skin and eyes.
• S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.

Hazard statements:

• H315 Causes skin irritation.
• H319 Causes serious eye irritation.
• H335 May cause respiratory irritation.

Precautionary statements:

• P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
• P264 Wash skin thoroughly after handling.
• P271 Use only outdoors or in a well-ventilated area.
• P280 Wear protective gloves/ eye protection/ face protection.
• P302 + P352 IF ON SKIN: Wash with plenty of soap and water.
• P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
• P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

D-AP5 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-411)

Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.

• Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
• Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
• Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
• QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
• Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity

To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).

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