| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Source | Endogenous metabolite — Human Gut Microbiota Metabolites |
| Molecular weight | |
| Molecular formula | C6H11Na2O9P |
| Purity | |
| Activity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
D-Fructose 1-phosphate disodium is a key intermediate metabolite in the fructose metabolic pathway. As a signaling molecule linking fructose metabolism to glucose metabolic regulation, it acts as an allosteric modulator that counteracts the inhibitory effect of the glucokinase-regulatory protein complex, finely tuning the direction of hepatic glucose metabolism at the substrate level[1][2]. It is an endogenous metabolite supplied as a white to off-white solid (C6H11Na2O9P, MW 304.10) at 99.75% purity.
Physical & Chemical Properties
| CAS Number | 71662-09-4 |
|---|---|
| Molecular Formula | C6H11Na2O9P |
| Molecular Weight | 304.10 g/mol |
| Purity | 99.75% |
| Appearance | Solid |
| Color | White to off-white |
| Structure Classification | Others |
| SMILES | O[C@H](C(COP(O[Na])(O[Na])=O)=O)[C@@H]([C@@H](CO)O)O |
| Signaling Pathway | Metabolic Enzyme/Protease |
| Bioactivity Class | Human Endogenous Metabolite |
| Initial Source | Endogenous metabolite — Human Gut Microbiota Metabolites |
| Solubility | In Vitro: H2O: 200 mg/mL (657.68 mM; Requires sonication) |
| Storage | -20°C, stored under nitrogen. In solvent: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| H2O | 200 mg/mL (657.68 mM) | requires sonication |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); stored under nitrogen; avoid repeated freeze-thaw cycles.
If water is used as the stock solvent, dilute to the working solution and sterilize it through a 0.22 μm filter before use.
Data provided by the manufacturer.
In Vitro
In isolated hepatocytes from fed rats, D-Fructose 1-phosphate disodium stimulates glucokinase activity with a half-maximal effective dose of 30 pmol/mg protein, and glucagon attenuates this stimulation[1]. D-Fructose 1-phosphate disodium (1 mM) is a specific substrate for Clostridioides difficile fructose-1-phosphate kinase, with a Km value of 160 μM, and sulfate and phosphate ions inhibit it[1]. The rat liver GKRP-GCK complex is directly dissociated by D-Fructose 1-phosphate disodium, which relieves the GKRP-mediated inhibition of GCK[2]. In intestinal epithelial cells, D-Fructose 1-phosphate disodium inhibits PKM2, thereby driving HIF-1α activation as well as hypoxic cell survival, villus elongation, and enhanced nutrient absorption[2].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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Unveiling the fructose metabolism system in Staphylococcus aureus: insights into the regulatory role of FruR and the FruRKT operon in bacterial fitness. BMC Microbiol 2024 Jan 4;24(1):13. PMID: 38177984
