| Field | Specification |
|---|---|
| Alternative names | D-Ribose |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C5H10O5 |
| Purity | |
| Activity | |
| SMILES | |
| Form | Oil |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
D-Ribofuranose, also known as D-Ribose, is an endogenous metabolite found in cerebrospinal fluid. It can be used in research on Ribose 5-Phosphate Isomerase Deficiency and Medium-Chain Acyl-CoA Dehydrogenase Deficiency[1][2]. The compound is supplied as a white to off-white oil (C5H10O5, MW 150.13) at 97.0% purity.
Physical & Chemical Properties
| CAS Number | 613-83-2 |
|---|---|
| Molecular Formula | C5H10O5 |
| Molecular Weight | 150.13 g/mol |
| Purity | 97.0% |
| Appearance | Oil |
| Color | White to off-white |
| SMILES | OC1[C@@H]([C@@H]([C@@H](CO)O1)O)O |
| Signaling Pathway | Metabolic Enzyme/Protease |
| Bioactivity Class | Microbial Metabolite |
| Solubility | In Vitro: H2O: 100 mg/mL (666.09 mM; Requires sonication) DMSO: 25 mg/mL (166.52 mM; Requires sonication; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | 4°C, sealed storage, away from moisture. In solvent: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| H2O | 100 mg/mL (666.09 mM) | requires sonication |
| DMSO | 25 mg/mL (166.52 mM) | requires sonication; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); sealed storage, away from moisture; avoid repeated freeze-thaw cycles.
If water is used as the stock solvent, dilute to the working solution and sterilize it through a 0.22 μm filter before use.
In Vivo
Choose the formulation that suits the animal model and route of administration; percentages are volume ratios of the final working solution. Start from a clear DMSO stock (see In Vitro above), add the co-solvents one at a time in the order listed, mixing after each addition, and prepare the working solution fresh on the day of dosing. If precipitation or phase separation occurs, gentle warming or sonication can help.
Protocol 1
| Composition | 10% DMSO + 40% PEG300 + 5% Tween-80 + 45% saline |
|---|---|
| Result | ≥ 2.5 mg/mL (16.65 mM); clear solution |
| How to prepare | Gives a clear solution at ≥ 2.5 mg/mL (saturation not determined). For 1 mL of working solution: add 100 μL DMSO stock (25.0 mg/mL) to 400 μL PEG300; then 50 μL Tween-80; then 450 μL saline to bring the volume to 1 mL. Saline: dissolve 0.9 g sodium chloride in ddH2O and make up to 100 mL. |
Protocol 2
| Composition | 10% DMSO + 90% (20% SBE-β-CD in saline) |
|---|---|
| Result | ≥ 2.5 mg/mL (16.65 mM); clear solution |
| How to prepare | Gives a clear solution at ≥ 2.5 mg/mL (saturation not determined). For 1 mL of working solution: add 100 μL DMSO stock (25.0 mg/mL) to 900 μL 20% SBE-β-CD in saline. 20% SBE-β-CD in saline: dissolve 2 g SBE-β-CD powder in 10 mL saline until clear (4°C, store up to one week). |
Protocol 3
| Composition | 10% DMSO + 90% Corn Oil |
|---|---|
| Result | ≥ 2.5 mg/mL (16.65 mM); clear solution |
| How to prepare | Gives a clear solution at ≥ 2.5 mg/mL (saturation not determined). Use with caution if continuous dosing will exceed two weeks. For 1 mL of working solution: add 100 μL DMSO stock (25.0 mg/mL) to 900 μL corn oil. |
Data provided by the manufacturer.
In Vitro
The Kyoto Encyclopedia of Genes and Genomes annotates the ~1900 metabolic enzymes encoded in our genome and their substrates and products, and metabolites in these groups are defined as endogenous metabolites. The literature clearly documents toxic properties for many of these metabolites[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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Suppressing neuroinflammation by Shenfu injection against ischemic stroke in mice via inhibiting RAGE-PI3K-Akt pathway. Phytomedicine 2025 Aug:144:156940. PMID: 40480024
