| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C18H29ClN2O3 |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Dap-NE hydrochloride is a dipeptide hydrochloride that functions as a cleavable ADC linker. It can be used to connect antibody and toxin (cytotoxin) molecules in the synthesis of antibody-drug conjugates (ADCs). It is supplied as a white to off-white solid (C18H29ClN2O3, MW 356.89) at 100% purity.
Physical & Chemical Properties
| CAS Number | 2019182-02-4 |
|---|---|
| Molecular Formula | C18H29ClN2O3 |
| Molecular Weight | 356.89 g/mol |
| Purity | 100% |
| Appearance | Solid |
| Color | White to off-white |
| SMILES | O=C(N[C@H](C)[C@@H](O)C1=CC=CC=C1)[C@H](C)[C@@H](OC)[C@H]2NCCC2.Cl |
| Signaling Pathway | Antibody-Drug Conjugate/ADC Related |
| Solubility | In Vitro: DMSO: 100 mg/mL (280.20 mM; Requires sonication; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | 4°C, stored under nitrogen, away from moisture. In solvent: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 100 mg/mL (280.20 mM) | requires sonication; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); stored under nitrogen, away from moisture; avoid repeated freeze-thaw cycles.
Data provided by the manufacturer.
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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