| Field | Specification |
|---|---|
| Alternative names | N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide |
| CAS no. | |
| Applications | |
| Source | Synthetic |
| Molecular weight | |
| Molecular formula | C22H26ClN7O2S |
| Purity | |
| Bioactivity | Inhibitor |
| Activity | |
| Solubility | Soluble in DMSO (200 mg/ml), ethanol (very poorly ), and water (very poorly ) |
| SMILES | |
| InChIKey | |
| Form | Crystalline solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Dasatinib is a dual Src and Abl kinase inhibitor with significantly greater potency against BCR-ABL than imatinib. In neuroscience, Src family kinases are involved in synaptic signaling, neuroinflammation, and blood-brain barrier integrity. Dasatinib is used to investigate the role of tyrosine kinase signaling in neurodegenerative diseases and has shown potential in modulating microglial activation and reducing neuroinflammatory responses. Its ability to cross the blood-brain barrier and inhibit multiple kinases makes it a promising candidate for repurposing in neurodegenerative and neuroinflammatory conditions.
Acute Toxicity:
Oral, Category 3
Toxic To Reproduction, Category 1B
Target Organ Systemic Toxicity (single exposure), Category 2
Target Organ Systemic Toxicity (repeated exposure), Category 2
Safety Phrases:
- S22 - Do not breathe dust.
- S24/25 - Avoid contact with skin and eyes.
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
H301:
Toxic if swallowed.
H360:
May damage fertility or the unborn child.
H370:
Causes damage to organs {uterus, testicles,ovaries}.
H373:
May cause damage to {uterus, testicles,ovaries} through prolonged or repeated exposure.
P264:
Wash {hands} thoroughly after handling.
P201:
Obtain special instructions before use.
P202:
Do not handle until all safety precautions have been read and understood.
P281:
Use personal protective equipment as required.
P260:
- Do not breathe {dust/fume/gas/mist/vapours/spray}.
- P301+310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P330:
- Rinse mouth.
- P308+313: IF exposed or concerned: Get medical attentiodvice.
P312:
Call a {POISON CENTER/doctor/...} if you feel unwell.
P314:
Get medical attentiodvice if you feel unwell.
Dasatinib (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-440)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
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