| Field | Specification |
|---|---|
| Applications | |
| Molecular weight | |
| Molecular formula | C35H45N3O10S3 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Deac-SS-Biotin is a potent antitumor agent that offers improved tumor targeting and reduced off-target toxicity. It enters cells via biotin-mediated internalization, and when combined with DTT (a glutathione mimetic) it can effectively inhibit microtubule assembly and shows greater antitumor activity[1]. It has a molecular formula of C35H45N3O10S3 and a molecular weight of 763.94 g/mol.
Physical & Chemical Properties
| Molecular Formula | C35H45N3O10S3 |
|---|---|
| Molecular Weight | 763.94 g/mol |
| SMILES | [H][C@]12NC(N[C@]1(CS[C@H]2CCCCC(OCCSSCCOC(N[C@H]3CCC4=C(C5=CC=C(C(C=C53)=O)OC)C=C(C(OC)=C4OC)OC)=O)=O)[H])=O |
| Signaling Pathway | Cell Cycle/DNA Damage; Cytoskeleton |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
Deac-SS-Biotin (5 μM; 24 h) shows marked reduction-responsive drug release[1]. Biotin effectively prevents Deac-SS-Biotin from binding the biotin receptor, which blocks its cellular uptake[1]. Deac-SS-Biotin effectively inhibits microtubule assembly and shows greater antitumor activity (5 μM, 5 μM and 10 μM DTT; 0-80 min)[1].
Cell Proliferation Assay[1]
| Cell Line | SGC-7901, A549, Hela, L929 cells |
|---|---|
| Concentration | 0-20 μM |
| Incubation Time | 72 h |
| Result | Showed potent antiproliferative activity with IC50s of 0.124, 0.085, 0.108, 4.22 μM for SGC-7901, A549, Hela, L929 cells, respectively. |
Cell Viability Assay[1]
- Cell Line: A549 cells
- Concentration: 0.17 μM
- Incubation Time:
- Result: Increased the cell viability from 23.6% to 68.9% with the increase of biotin concentration from 0.075 to 0.60 μM.
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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