| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | (7aS,13aS)-9,10-Dimethoxy-3,3-dimethyl-13,13a-dihydro-3H-chromeno[3,4-b]pyrano[2,3-h]chromen-7(7aH)-one |
| Cas No. | |
| Form | Cream Solid |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble to 50 mM in ethanol and to 100 mM in DMSO |
| Source | Synthetic |
| Storage |
Deguelin is a rotenoid compound with notable anti-cancer and neurotoxic properties. It inhibits mitochondrial complex I, leading to increased oxidative stress and apoptosis in cancer cells. However, its neurotoxicity has raised concerns, particularly due to its association with Parkinsonian symptoms in animal models. Deguelin's dual role as a therapeutic agent and neurotoxin makes it a compound of interest in neurodegenerative disease research, especially for understanding mitochondrial dysfunction and oxidative stress pathways in dopaminergic neurons.
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin.
Safety Phrases:
- S22 - Do not breathe dust
- S24/25 - Avoid contact with skin and eyes
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Deguelin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-251)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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2. Caboni P., et al. (2004) Chem Res. Toxicol. 17(11): 1540-1548.
