| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C32H40ClF3N6O6S2 |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Deltasonamide 1 TFA is a PDE6δ-KRas inhibitor. It can inhibit PDE6δ-KRas with a KD of 203 pM and can be used in tumor research[1]. It is supplied as a white to off-white solid (C32H40ClF3N6O6S2, MW 761.27).
Physical & Chemical Properties
| CAS Number | 2235358-73-1 |
|---|---|
| Molecular Formula | C32H40ClF3N6O6S2 |
| Molecular Weight | 761.27 g/mol |
| Appearance | Solid |
| Color | White to off-white |
| SMILES | O=S(C1=CC=C(S(=O)(N(CC2=NC(NC)=NC=C2)CC3CCNCC3)=O)C=C1)(N(CC4=CC=C(Cl)C=C4)C5CCCC5)=O.O=C(O)C(F)(F)F |
| Signaling Pathway | Metabolic Enzyme/Protease |
| Solubility | In Vitro: H2O: 200 mg/mL (262.72 mM; Requires sonication) |
| Storage | 4°C, sealed storage, away from moisture. In solvent: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
Activity & Target
KD: 203 pM (PDE6δ-KRas)[1]
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| H2O | 200 mg/mL (262.72 mM) | requires sonication |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); sealed storage, away from moisture; avoid repeated freeze-thaw cycles.
If water is used as the stock solvent, dilute to the working solution and sterilize it through a 0.22 μm filter before use.
Data provided by the manufacturer.
In Vitro
Deltasonamide 1 can inhibit PDE6δ-KRas, with a KD of 203 pM[1]. Deltasonamide 1 binds PDE6δ through up to 7 hydrogen bonds, giving picomolar affinity[1]. Deltasonamide 1 strongly reduces proliferation[1].
Cell Proliferation Assay[1]
| Cell Line | RTCA of hPDAC cell lines |
|---|---|
| Concentration | 0.375, 0.75, 1.5, 3, 6, 12 μM |
| Incubation Time | 60 h |
| Result | Inhibited proliferation of human pancreatic cancer cell lines. |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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