| Field | Specification |
|---|---|
| Alternative names | Diethylamine NONOate; NOC-18 |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C4H13N5O2 |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
DETA NONOate, also known as Diethylamine NONOate or NOC-18, is an exogenous nitric oxide (NO) donor. It provides a slow, long-acting release of normal amounts of NO[1][2]. It is supplied as a white to off-white solid (C4H13N5O2, MW 163.18) at 98.10% purity.
Physical & Chemical Properties
| CAS Number | 146724-94-9 |
|---|---|
| Molecular Formula | C4H13N5O2 |
| Molecular Weight | 163.18 g/mol |
| Purity | 98.10% |
| Appearance | Solid |
| Color | White to off-white |
| SMILES | O=NN(O)N(CCN)CCN |
| Signaling Pathway | Immunology/Inflammation |
| Solubility | In Vitro: H2O: 50 mg/mL (306.41 mM; Requires sonication) DMSO: < 1 mg/mL (insoluble or slightly soluble) |
| Storage | -80°C. |
| Shipping | Shipping with dry ice. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| H2O | 50 mg/mL (306.41 mM) | requires sonication |
| DMSO | < 1 mg/mL | insoluble or slightly soluble |
Aliquot the stock solution and store it at -80°C (up to 6 months); avoid repeated freeze-thaw cycles.
If water is used as the stock solvent, dilute to the working solution and sterilize it through a 0.22 μm filter before use.
Data provided by the manufacturer.
In Vitro
DETA NONOate (100 μM; 16 h) induces growth of the Mycobacterium abscessus complex (MABC) R morphotype by reducing glycopeptidolipid (GPL) expression in M. abscessus subspecies abscessus (Mab)[3].
In Vivo
In the rat formalin model, DETA NONOate (15-150 μg/rat, i.c.v., once) has a nociceptive effect[2]. DETA NONOate (1 μM) prevents apoptotic cell death and lessens the cardiac mitochondrial injury caused by ischemia or ischemia/reperfusion[4].
| Animal Model | Sprague-Dawley rats (Sixty-two, male, 200-250 g)[2] |
|---|---|
| Dosage | 15 or 150 μg per rat |
| Administration | i.c.v., once |
| Result | Accelerated the nociception in a dose-dependent manner, and this acceleration was completely abolished by Methylene Blue. |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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