| Field | Specification |
|---|---|
| Target | |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C22H25Cl2NO3 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
DETQ is a selective, allosteric, orally active potentiator of the dopamine D1 receptor. In HEK293 cells expressing the human D1 receptor, it increases cAMP with an EC50 of 5.8 nM and a Kb of 26 nM; it is roughly 30-fold less potent at the rat and mouse D1 receptors and inactive at the human D5 receptor[1]. Its molecular formula is C22H25Cl2NO3, with a molecular weight of 422.34 g/mol.
Physical & Chemical Properties
| CAS Number | 1638667-81-8 |
|---|---|
| Molecular Formula | C22H25Cl2NO3 |
| Molecular Weight | 422.34 g/mol |
| SMILES | C[C@@H]1N(C(CC2=C(Cl)C=CC=C2Cl)=O)[C@@H](CO)CC3=C1C=CC=C3C(C)(O)C |
| Target | Human D 1 Receptor |
| Signaling Pathway | GPCR/G Protein; Neuronal Signaling |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
IC50 & Target[1]
|
Human D1 Receptor 5.8 nM (EC50) |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vivo
In male humanized D1 receptor knock-in mice, a single i.p. dose of DETQ (10 mg/kg) ameliorates subchronic Phencyclidine-induced deficits in object recognition memory and enhances cortical acetylcholine efflux[2].
| Animal Model | Mice genetically modified to express the human D1 receptor ("hD1 mice")[2] |
|---|---|
| Dosage | 10 mg/kg |
| Administration | i.p.; once |
| Result | Ameliorated subchronic Phencyclidine-induced object recognition memory deficits. |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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