| Field | Specification |
|---|---|
| Alternative names | (11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione |
| CAS no. | |
| Applications | |
| Source | Synthetic |
| Molecular weight | |
| Molecular formula | C22H29FO5 |
| Purity | |
| Bioactivity | Inducer |
| Activity | |
| Solubility | Soluble to 100 mM in DMSO |
| SMILES | |
| InChIKey | |
| Form | White solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Dexamethasone is a potent synthetic glucocorticoid with anti-inflammatory and immunosuppressive properties. In neuroscience, it is used to reduce cerebral edema and inflammation associated with brain tumors, traumatic brain injury, and neurodegenerative conditions. Dexamethasone modulates the hypothalamic-pituitary-adrenal (HPA) axis and suppresses pro-inflammatory cytokine production, which can mitigate neuroinflammation and neuronal damage. Its role in regulating glucocorticoid receptor signaling also makes it relevant in studies of stress-related neuropsychiatric disorders.
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin.
Safety Phrases:
- S22 - Do not breathe dust
- S24/25 - Avoid contact with skin and eyes
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Risk Phrases:
- R62 - Possible risk of impaired fertility
- R68- Possible risk of irreversible effects
Hazard Phrases:
H315-H317-H319-H334-H335
Precautionary Phrases:
P261-P280-P305 + P351 + P338-P342 + P311
Dexamethasone (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-259)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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2. Hasan E.A., Jessop D.S., Power L.L. Monk P.T. and Kirwan J.R. (2009) Int J Endocrinol. 2009: 391284.
