| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C54H84N4O8 |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
di-Pal-MTO is a palm oil-based lipid formed by combining the anticancer agent mitoxantrone (MTO) with palmitoleic acid. When nanoparticles of mono-Pal-MTO and di-Pal-MTO are combined at a 1:1 molar ratio, they deliver siRNA to cells effectively and enhance anticancer activity[1]. It is supplied as a dark purple to black solid (C54H84N4O8, MW 917.27) at 98.37% purity.
Physical & Chemical Properties
| CAS Number | 1349197-90-5 |
|---|---|
| Molecular Formula | C54H84N4O8 |
| Molecular Weight | 917.27 g/mol |
| Purity | 98.37% |
| Appearance | Solid |
| Color | Dark purple to black |
| SMILES | CCCCCC/C=C\CCCCCCCC(OCCNCCNC1=C2C(C(C3=C(O)C=CC(O)=C3C2=O)=O)=C(C=C1)NCCNCCOC(CCCCCCC/C=C\CCCCCC)=O)=O |
| Signaling Pathway | Metabolic Enzyme/Protease |
| Solubility | In Vitro: DMSO: 10 mg/mL (10.90 mM; Requires sonication; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | 4°C, sealed storage, away from moisture and light. In solvent: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 10 mg/mL (10.90 mM) | requires sonication; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); sealed storage, away from moisture and light; avoid repeated freeze-thaw cycles.
Data provided by the manufacturer.
In Vitro
Nanoparticles of mono-Pal-MTO and di-Pal-MTO in a 1:1 molar ratio (md11-Pal-MTO) deliver the Mcl-1-specific anticancer siRNA (siMcl-1) and enhance in vitro antitumor activity, with tumor cell viability reduced by 81% and tumor size by 83%. With Lipofectamine 2000-mediated transfection of siMcl-1, tumor cell viability falls by 68%[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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