| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C61H58FN9O12 |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
DIBAC-GGFG-NH2CH2-Dxd, a Camptothecin derivative is a linker-payload used in protein-agent conjugates[1]. Dxd itself can serve as a payload for the antibody-drug conjugate DS-8201a. As a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules[1][2]. It is supplied as a light yellow to yellow solid (C61H58FN9O12, MW 1128.16) at 98.57% purity.
Physical & Chemical Properties
| CAS Number | 2758875-01-1 |
|---|---|
| Molecular Formula | C61H58FN9O12 |
| Molecular Weight | 1128.16 g/mol |
| Purity | 98.57% |
| Appearance | Solid |
| Color | Light yellow to yellow |
| SMILES | O=C(N1C2=CC=CC=C2C#CC3=CC=CC=C3C1)CCC(NCC(NCC(N[C@@H](CC4=CC=CC=C4)C(NCC(NCOCC(N[C@@H]5C6=C7C(C(N8C7)=CC([C@](O)(C(OC9)=O)CC)=C9C8=O)=NC%10=CC(F)=C(C)C(CC5)=C%106)=O)=O)=O)=O)=O)=O |
| Signaling Pathway | Antibody-Drug Conjugate/ADC Related |
| Solubility | In Vitro: DMSO: 100 mg/mL (88.64 mM; Requires sonication; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | 4°C, stored under nitrogen, away from moisture. In solvent: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
[1]. Amy Han, et al. Camptothecin analogs conjugated to a glutamine residue in a protein, and their use. WO2022015656A1
[2]. Protein-drug conjugates comprising camptothecin analogs and methods of use thereof
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 100 mg/mL (88.64 mM) | requires sonication; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); stored under nitrogen, away from moisture; avoid repeated freeze-thaw cycles.
Data provided by the manufacturer.
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