| Field | Specification |
|---|---|
| Target | |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C17H18O4 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Dihydroflavokawin B is a selective COX-1 inhibitor (IC50 1.22 μM) that weakly inhibits COX-2 and 5-LOX. It also inhibits promastigote forms of Leishmania panamensis and Leishmania braziliensis, and blocks rabbit platelet aggregation induced by arachidonic acid, platelet activating factor, and adenosine diphosphate. The compound exhibits in vitro anti-inflammatory activity and can be used in leishmaniasis research[1][2]. It has the molecular formula C17H18O4 and a molecular weight of 286.33 g/mol.
Physical & Chemical Properties
| CAS Number | 3791-76-2 |
|---|---|
| Molecular Formula | C17H18O4 |
| Molecular Weight | 286.33 g/mol |
| SMILES | O=C(C=1C(O)=CC(OC)=CC1OC)CCC=2C=CC=CC2 |
| Target | COX-1, COX-2 |
| Signaling Pathway | Immunology/Inflammation; Anti-infection |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
IC50 & Target[1]
|
COX-1 1.22 μM (IC50) |
COX-2 457 μM (IC50) |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
Dihydroflavokawin B (1.5625-200 μg/mL; 72 h) exhibits leishmanicidal activity against L. panamensis promastigotes, with EC50 values of 19.9 μg/mL and 25.0 μg/mL, and is cytotoxic to J774 murine macrophages, with an LC50 of 49.02 μg/mL, which gives a selectivity index of 2[1]. Dihydroflavokawin B is a potent inhibitor of ovine COX-1 (IC50 of 1.22 μM) but only weakly inhibits ovine COX-2 (IC50 of 457 μM) and potato 5-LOX (IC50 of 127 μM)[2]. Dihydroflavokawin B inhibits rabbit platelet aggregation induced by Arachidonic acid (IC50 = 43.2 μM) more potently than aggregation induced by PAF or ADP[2].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
Can’t find the compound you’re looking for?
Send the CAS or structure and your specs. We can help source it, suggest close equivalents, or discuss custom synthesis with the right QC documentation (RUO).
