| Field | Specification |
|---|---|
| Target | |
| CAS no. | |
| Applications | |
| Source | Plant — Annonaceae Monodora minor Engl. & Diels |
| Molecular weight | |
| Molecular formula | C30H28O6 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Diuvaretin is an antimalarial, C-phenylated dihydrochalcone that can be isolated from the roots of U. acuminata. It increases Caspase-3 activity to trigger apoptosis and shows antiparasitic activity against Plasmodium falciparum, supporting its use in the research of promyelocytic leukemia and malaria[1][2]. It has the molecular formula C30H28O6 and a molecular weight of 484.55 g/mol.
Physical & Chemical Properties
| CAS Number | 61463-04-5 |
|---|---|
| Molecular Formula | C30H28O6 |
| Molecular Weight | 484.55 g/mol |
| Structure Classification | Phenols Polyphenols |
| SMILES | O=C(C=1C(O)=C(C(O)=C(C1OC)CC=2C=CC=CC2O)CC=3C=CC=CC3O)CCC=4C=CC=CC4 |
| Target | Caspase-3, Plasmodium |
| Signaling Pathway | Apoptosis; Anti-infection |
| Initial Source | Plant — Annonaceae Monodora minor Engl. & Diels |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
Diuvaretin (48 h) potently suppresses proliferation of promyelocytic leukemia HL-60 cells, giving an IC50 value of 6.1 μM[1]. In promyelocytic leukemia HL-60 cells, Diuvaretin (10-20 μM; 24-48 h) causes morphological changes of apoptosis (chromatin condensation and nuclear degradation)[1]. G1 phase arrest and the formation of a sub-G1 peak are induced by Diuvaretin (5-20 μM; 6-24 h) in promyelocytic leukemia HL-60 cells, whereas 5 μM Diuvaretin has no effect on cell cycle distribution[1]. Diuvaretin suppresses growth of Plasmodium falciparum, with an IC50 of 3.5 mg/mL[2].
Cell Cytotoxicity Assay[1]
| Cell Line | human promyelocytic leukemia HL-60 cells |
|---|---|
| Concentration | dose-response |
| Incubation Time | 48 h |
| Result | Exhibited dose-dependent growth inhibition of HL-60 cells, with an IC50 value of 6.1 μM. Showed stronger cytotoxicity than isouvaretin and slightly stronger cytotoxicity than uvaretin. |
Cell Cycle Analysis[1]
| Cell Line | human promyelocytic leukemia HL-60 cells |
|---|---|
| Concentration | 5 μM, 10 μM, 20 μM |
| Incubation Time | 6 h, 12 h, 24 h |
| Result | Induced accumulation of cells in the G1 phase and the appearance of a sub-G1 peak (indicative of apoptotic cells) at 10 μM or 20 μM for 12 h or 24 h. Showed no cell cycle changes with 5 μM across 6-24 h incubation times. |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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