| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Concentration | |
| Form | Lyophilized powder. |
| Product Type | |
| Purity | |
| Reconstitution | |
| Shipping | |
| Solubility | Soluble in water, 1eq NaOH and aqueous buffers.Centrifuge all product preparations before use (10000 x g 5 min). |
| Source | Synthetic |
| Storage | |
| Target |
Product details
- Chemical name: 2-amino-3-phosphonopropanoic acid.
- Also known as: DL-2-Amino-3-phosphonopropionic acid
- CAS number: 5652-28-8
- Molecular formula: C3H8NO5P.
- Purity: >97%
- Concentration: 0.1-10 mM.
- Form: Lyophilized powder.
- Solubility: Soluble in water, 1eq NaOH and aqueous buffers.Centrifuge all product preparations before use (10000 x g 5 min).
- Reconstitution: Soluble in water, 1eq NaOH and aqueous buffers.Centrifuge all product preparations before use (10000 x g 5 min).
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: mGluR1
- Source: Synthetic
- Activity: DL-AP3 is a selective competitive antagonist of group I metabotropic glutamate receptors, at 1 mM suppressing mGluR1 response in an agonist dependent manner1.
- Alternative names: DL-2-Amino-3-phosphonopropionic acid
Scientific background
DL-AP3 is a racemic compound of 2-amino-3-phosphonopropionic acid that acts as a potent and competitive antagonist of mGluR1 receptors. It demonstrates an IC50 value of 1 mM for rat mGluR1 when challenged with glutamate2. DL-AP3 has neuroprotective effects in the gerbil model of global ischemia1,2.Glutamate is the most abundant excitatory neurotransmitter in the central nervous system. It modulates the activity of many types of synapses by activating, in part, metabotropic glutamate receptors (mGluRs), members of the G-protein coupled receptor (GPCR) superfamily. These receptors are divided into three groups based on sequence homology with a total of eight subtypes, mGluR1 to mGluR8. Type 1 mGluRs are mainly detected on post-synaptic neurons and affect the fate of neuronal progenitor cells and neural stem cells, and are important for the formation of the hippocampus3.
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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