| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Concentration | |
| Form | Lyophilized powder. |
| Product Type | |
| Purity | |
| Reconstitution | |
| Shipping | |
| Solubility | 100 mM in 1N NaOH solution. Centrifuge all product preparations before use (10,000 x g for 1 min). |
| Source | Synthetic |
| Storage | |
| Target |
Product details
- Chemical name: 2-amino-7-phosphonoheptanoic acid.
- Also known as: APH
- CAS number: 78966-69-5
- Molecular formula: C7H16NO5P.
- Purity: >99%
- Concentration: 1-250 µM.
- Form: Lyophilized powder.
- Solubility: 100 mM in 1N NaOH solution. Centrifuge all product preparations before use (10,000 x g for 1 min).
- Reconstitution: 100 mM in 1N NaOH solution. Centrifuge all product preparations before use (10,000 x g for 1 min).
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: NMDA receptors
- Source: Synthetic
- Activity: DL-AP7 is an NMDA receptor antagonist1.
- Alternative names: APH
Scientific background
DL-AP7 (APH) is a competitive N-methyl-D-aspartate (NMDA) receptor antagonist. The mechanism of action of DL-AP7 is to compete with agonists over the recognition site of the NMDA receptor in order to prevent the receptor's activation.Several studies have shown that NMDA receptor blockade evokes changes of systemic pressure; DL-AP7 administration may increase blood pressure. This finding indicates that peripherally, NMDA receptors may take part in regulating the cardiovascular system1,2.NMDA receptors play an important role in a variety of cellular processes and brain functions such as synaptic plasticity, addiction and stroke. NMDA receptors mediate several physiological functions including learning and memory formation, they play a role in glutamate excitotoxicity and are involved in many neurodegenerative conditions including Alzheimer's disease3.
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
Can’t find the compound you’re looking for?
Send the CAS or structure and your specs. We can help source it, suggest close equivalents, or discuss custom synthesis with the right QC documentation (RUO).
