| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Concentration | |
| Form | Lyophilized powder. |
| Product Type | |
| Purity | |
| Reconstitution | |
| Shipping | |
| Solubility | Up to 100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min). |
| Source | Synthetic |
| Storage | |
| Target |
Product details
- Chemical name: 4-O-[(2S)-3,3-dimethylbutan-2-yl] 2-O-propyl 3,5-dimethyl-1H-pyrrole-2,4-dicarboxylate.
- Also known as: CHEMBL232052, GTPL1383, BDBM50204428
- PubChem CID: 44431042
- Molecular formula: C17H27NO4.
- Purity: >97%
- Concentration: 1 nM - 1 µM.
- Form: Lyophilized powder.
- Solubility: Up to 100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
- Reconstitution: Up to 100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: mGluR1
- Source: Synthetic
- Activity: DM-PPP is a selective and non-competitive antagonist of mGluR1 receptors. It inhibits the receptor in CHO cells with an IC50 of 15.8 nM1.
- Alternative names: CHEMBL232052, GTPL1383, BDBM50204428
Scientific background
DM-PPP is a synthetic compound that acts as a selective and non-competitive antagonist of mGluR1 receptors with an IC50 value of 15.8 nM1. The compound interacts with the 7 transmembrane (7TM) domain of the receptor. In several animal models DM-PPP shows antinociceptive properties1.Metabotropic glutamate receptors (mGluRs) are G-protein coupled receptors (GPCR) that play an important role in synaptic plasticity and other neuro-physiological and pathological processes including a major role in central sensitization and neuropathic pain. Type 1 mGluRs are mainly expressed on post-synaptic neurons and are known to affect the fate of neuronal progenitor cells and neural stem cell and the formation of the hippocampus2.
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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