| Field | Specification |
|---|---|
| Alternative names | Maytansinoid DM3 |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C37H52ClN3O10S |
| Purity | |
| Activity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
DM3, also known as Maytansinoid DM3, is a Maytansine analog bearing disulfide or thiol groups and acts as a tubulin inhibitor. It serves as a cytotoxic moiety in antibody-drug conjugates (ADCs)[1][2]. It is supplied as a white to off-white solid (C37H52ClN3O10S, MW 766.34) at 95.59% purity.
Physical & Chemical Properties
| CAS Number | 796073-54-6 |
|---|---|
| Molecular Formula | C37H52ClN3O10S |
| Molecular Weight | 766.34 g/mol |
| Purity | 95.59% |
| Appearance | Solid |
| Color | White to off-white |
| SMILES | C[C@]12[C@H]([C@@H]([C@](O3)([H])C[C@]([C@](/C=C/C=C(C)/CC4=CC(N(C)C(C[C@]2([H])OC([C@H](C)N(C)C(CCC(S)C)=O)=O)=O)=C(C(OC)=C4)Cl)([H])OC)(NC3=O)O)C)O1 |
| Signaling Pathway | Antibody-Drug Conjugate/ADC Related; Cytoskeleton; Cell Cycle/DNA Damage |
| Bioactivity Class | Maytansinoids |
| Solubility | In Vitro: DMSO: 100 mg/mL (130.49 mM; Requires sonication and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | Powder: -20°C, 3 years. In solvent: -80°C, 6 months; -20°C, 1 month. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 100 mg/mL (130.49 mM) | requires sonication and warming and heat to 60°C; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); avoid repeated freeze-thaw cycles.
Data provided by the manufacturer.
In Vitro
DM3 carries disulfide bonds or thiol groups that allow covalent linkage to monoclonal antibodies (mAb)[1]. By inhibiting microtubule dynamic instability, DM3 exerts a strong anti-mitotic effect[2].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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