| Field | Specification |
|---|---|
| Applications | |
| Molecular weight | |
| Molecular formula | C18H18Cl2N4O4S |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
DNA gyrase B-IN-2 is a 2-aminobenzothiazole-based inhibitor of DNA gyrase B with promising activity against ESKAPE bacterial pathogens. It shows low nanomolar inhibition of DNA gyrase (IC50 < 10 nM) and broad-spectrum antibacterial activity against the ESKAPE group, with a minimum inhibitory concentration below 0.03 μg/mL for most Gram-positive strains and 4–16 μg/mL against the Gram-negative species E. coli, Acinetobacter baumannii, Pseudomonas aeruginosa and Klebsiella pneumoniae, and it can be used for infection research[1]. It is supplied as a light yellow to yellow solid (C18H18Cl2N4O4S, MW 457.33) at 99.77% purity.
Physical & Chemical Properties
| Molecular Formula | C18H18Cl2N4O4S |
|---|---|
| Molecular Weight | 457.33 g/mol |
| Purity | 99.77% |
| Appearance | Solid |
| Color | Light yellow to yellow |
| SMILES | O=C(O)C1=CC(SC(NC(C2=C(Cl)C(Cl)=C(C)N2)=O)=N3)=C3C=C1NCCCOC |
| Signaling Pathway | Anti-infection |
| Solubility | In Vitro: DMSO: 2 mg/mL (4.37 mM; Requires sonication and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
IC50 & Target
IC50: DNA gyrase (< 10 nM)[1].
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 2 mg/mL (4.37 mM) | requires sonication and warming and heat to 60°C; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); avoid repeated freeze-thaw cycles.
Data provided by the manufacturer.
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