| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C25H28N6O2 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
DNA-PK-IN-10 is an inhibitor of DNA-PK that can be used for research into breast cancer and non-small cell lung cancer[1]. It has the molecular formula C25H28N6O2 and a molecular weight of 444.53 g/mol.
Physical & Chemical Properties
| CAS Number | 2919315-89-0 |
|---|---|
| Molecular Formula | C25H28N6O2 |
| Molecular Weight | 444.53 g/mol |
| SMILES | O=C(N1C)N(C2CCC(NCCOC3=CC=NC4=C5)CC2)C(C1=CN6)=CC6=NC(C=C43)=C5C |
| Signaling Pathway | Cell Cycle/DNA Damage; PI3K/Akt/mTOR |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
[1]. Kuncheng C, et al. Dna-pk selective inhibitor, and preparation method therefor and use thereof. WO2023036156A1.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
In MDA-MB-468 cells, DNA-PK-IN-10 lowers viability with an IC50 of 11.2 nM[1].
In Vivo
In mice inoculated with NCI-H1703 cells, DNA-PK-IN-10 (30 mg/kg; administered twice a day) significantly suppresses tumor growth and is well tolerated[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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