| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | AMPK Inhibitor, Compound C, 6-[4-(2-Piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine |
| Cas No. | |
| Form | Yellow solid |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble in DMSO (4 mg/ml, warm) |
| Source | Synthetic |
| Storage |
Dorsomorphin is a potent, selective, and reversible inhibitor of AMP-activated protein kinase (AMPK), acting in an ATP-competitive manner. It also selectively inhibits bone morphogenetic protein (BMP) signaling. In neuroscience, Dorsomorphin is used to study the role of AMPK in neuronal energy metabolism, autophagy, and cell survival. AMPK dysregulation is implicated in neurodegenerative diseases such as Alzheimer’s and Parkinson’s, where impaired energy homeostasis contributes to neuronal dysfunction. Additionally, BMP signaling influences neural development and neuroinflammation. Dorsomorphin is a valuable tool for dissecting the interplay between metabolic stress, neurogenesis, and neurodegeneration.
Classification: Acute toxicity, Oral (Category 4), H302
Acute toxicity, Inhalation (Category 4), H332
Acute toxicity, Dermal (Category 4), H312
Safety Phrases:
- S22 - Do not breathe dust.
- S24/25 - Avoid contact with skin and eyes.
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H302 + H312 + H332 Harmful if swallowed, in contact with skin or if inhaled
Precautionary statements:
- P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
- P264 Wash skin thoroughly after handling.
- P270 Do not eat, drink or smoke when using this product.
- P271 Use only outdoors or in a well - ventilated area.
- P280 Wear protective gloves/ protective clothing.
- P301 + P312 IF SWALLOWED: Call a POISON CENTER or doctor/ physician if you feel unwell.
- P302 + P352 IF ON SKIN: Wash with plenty of soap and water.
- P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
Dorsomorphin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-443)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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2. Yu P.B., et al. (2008). Nat. Chem. Biol. 4(1): 33–41.
